Tricyclic inhibitors of the gpiibiiia receptor

Details Tricyclic inhibitors of the gpiibiiia receptor Tricyclic inhibitors of the gpiibiiia receptor

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/55 (2006.01) C07D 519/00 (2006.01)

Patent

CA 2166811

A tricyclic beazodiazepine derivative that acts as a nonpeptidyl platelet aggregation inhibitor is provided. This inhibitor potently inhibits fibrinogen binding to the GPII b III a receptor and is provided in therapeutic compositions for the treatment of diseases for which blocking platelet aggregation is indicated. These nonpeptidyl inhibitors an provided is combination with thrombolytics and anticoagulants.

L'invention concerne un dérivé tricyclique de benzodiazépine qui agit en tant qu'inhibiteur d'aggrégation plaquettaire différent du peptidyle. Cet inhibiteur inhibe fortement la liaison du fibrinogène au récepteur GPIIbIIIa et figure dans des compositions thérapeutiques destinées au traitement de maladies pour lesquelles il est indiqué de bloquer l'aggrégation plaquettaire. Ces inhibiteurs différents du peptidyle sont fournis en combinaison avec des agents thrombolytiques et anticoagulants.

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