C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 275/06 (2006.01) A61K 31/403 (2006.01) A61K 31/428 (2006.01) A61P 35/00 (2006.01) C07D 209/92 (2006.01)
Patent
CA 2432196
A compound of formula (I) wherein A and B are optionally substituted cyclohexenyl or phenyl groups, X is carbonyl or sulfonyl, and Y is 5-7 atoms- linker, is useful as histone deacetylase inhibitors, particularly for inhibiting cell proliferation.
La présente invention concerne un composé représenté par la formule (I) dans laquelle A et B représentent des groupes phényle ou cyclohexényle facultativement substitués, X représente carbonyle ou sulfonyle et Y représente un agent de liaison à 5-7 atomes. Ces composés sont utiles en tant qu'inhibiteurs de l'histone déacétylase, notamment pour inhiber la prolifération des cellules. Formule (I)
Georges Guy
Grossmann Adelbert
Mundigl Olaf
Sattelkau Tim
von Der Saal Wolfgang
F. Hoffmann-La Roche Ag
Gowling Lafleur Henderson Llp
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