Tricyclic orthofused heterocyclic compounds

Details Tricyclic orthofused heterocyclic compounds Tricyclic orthofused heterocyclic compounds

C - Chemistry, Metallurgy

07

D

260/246.1, 260/2

C07D 471/04 (2006.01) C07D 231/38 (2006.01) C07D 513/04 (2006.01)

Patent

CA 1117113

-1- NEW TRICYCLIC ORTHO-FUSED HETEROCYCLIC COMPOUNDS. Abstract of the disclosure: New tricyclic ortho-fused heterocyclic compounds of formula Image I wherein A is the group Image or the group Image a) b) in which R represents hydrogen, (C1- 4)alkyl, phenyl or tolyl and R1 may be (C1-4)alkyl, phenyl or tolyl, R2 is elected from (C1-4)alkyl, (C2-4)alkanoylmethyl, carbo- (C1-3)alkoxymethyl, hydroxy(C2-4)alkyl, halo(C2-4)alkyl and a group Image wherein R3 is an alkylene group from 2 to 4 carbon atoms and R4 and R5 independently represent hydrogen or (C1-4)- alkyl or, taken together with the nitrogen atom, a fully hydrogenated 5 or 6 memebered heterocyclic radical which may contain a further heteroatom selected from O, N and S and be optionally substituted by a (C1-4)alkyl or phenyl group, or R2 may represent nil the dotted lines x and y may represent nil or additional bonds; with the proviso that, when the symbol R2 linked to the oxygen atom is diffe- rent from nil, x is an additional bond and y and the other -2- symbol R2 represent nil; with the further proviso that, when the symbol R2 linked to the nitrogen atom is different from nil, y is an additional bond and x and the other sym- bol R2 represent nil; and salts therewith of pharmaceutical- ly acceptable acids. The compounds possess antiinflammatory, CNS-depressant and anti-anxiety utility.

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