C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 498/04 (2006.01) A61K 31/505 (2006.01) A61K 31/53 (2006.01) A61K 31/535 (2006.01) A61K 31/54 (2006.01) C07D 471/14 (2006.01) C07D 487/04 (2006.01) C07D 491/147 (2006.01) C07D 495/14 (2006.01) C07D 498/14 (2006.01) C07D 513/04 (2006.01) C07D 519/00 (2006.01)
Patent
CA 2134218
- 37 - Abstract The present invention concerns the new use of tricyclic pyrimidine derivatives for the production of pharmaceutical agents with an antiviral action. The invention in addition concerns new pyrimidine derivatives, processes for their production and pharmaceutical agents that contain these compounds. The invention concerns the use of tricyclic pyrimidine derivatives of the general formula I (I) Image for the production of pharmaceutical agents with an antiviral action, in which A denotes a carbocyclic or a heterocyclic ring, X can be an oxygen or sulphur atom or the group =NH, =N-C1-C6-alkyl or =S(O)2, Y can be an oxygen atom or the NH- or C1-C5 alkyl- amino group - 38 - R can be an aliphatic residue with 1-9 C atoms which can be substituted by phenyl or it denotes a phenyl ring, or it denotes a carbocyclic ring with 7-15 C atoms or a heterocyclic ring system, R1 denotes a hydrogen atom, an aliphatic residue with 1-6 C atoms or C1-C6 alkoxy, C1-C6 alkylmercapto, C1-C6 alkylsulfinyl, C1-C6 alkylsulfonyl, amino, C1- C6 alkylamino, di-C1-C6-alkylamino, sulfonamido, C1- C6 alkoxycarbonyl, carboxy, halogen, hydroxy, nitro, cyano, azido, phenyl or benzyloxy, R2, R3, R4 and R5 can, independently of each other, be the same or different and each denote hydrogen, C1- C6 alkyl, C1-C6 hydroxyalkyl, cyano, carboxy or C1- C6 alkoxycarbonyl or R2 and R4 denote a further bond between the C atoms to which they are bound, R6 denotes hydrogen or C1-C6 alkyl, m denotes 0 or 1 as well as tautomers, enantiomers, diastereomers and physiologically tolerated salts thereof.
Konig Bernhard
Leser Ulrike
Mertens Alfred
Zilch Harald
Boehringer Mannheim Gmbh
Swabey Ogilvy Renault
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