Tricyclic quinoxalinedione derivatives

Details Tricyclic quinoxalinedione derivatives Tricyclic quinoxalinedione derivatives

C - Chemistry, Metallurgy

07

D

C07D 471/06 (2006.01) A61K 31/495 (2006.01) B28B 1/40 (2006.01) B28B 21/48 (2006.01) C07C 271/22 (2006.01) C07C 279/24 (2006.01) C07C 323/44 (2006.01)

Patent

CA 2121609

- 81 - Abstract of Disclosure: A tricyclic quinoxalinedione derivative represented by the formula 1: Image wherein X represents hydrogen, alkyl, halogen, cyano, trifluoromethyl, or nitro; R1 represents hydrogen, alkyl, cycloalkyl, or cycloalkylalkyl; G represents -CONR2- or -NR2CO-, wherein R2 represents hydrogen or alkyl; J represents an acidic group or a group which is convertible thereto in vivo; E represents an basic group or a group which is convertible thereto in vivo; Y represents a single bond, alkylene, alkenylene, substituted alkylene, or Y1-Q-Y2, wherein Y1 represents a single bond or alkylene, Y2 represents alkylene, and Q represents a heteroatom selected from oxygen or sulfur; Z represents alkylene. or a pharmaceutically acceptable salt thereof, these compounds are selective antagonists of glycine binding site of the NMDA receptor.

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