Tricyclic quinoxalinediones

Details Tricyclic quinoxalinediones Tricyclic quinoxalinediones

C - Chemistry, Metallurgy

07

D

C07D 471/06 (2006.01) A61K 31/495 (2006.01) C07D 487/06 (2006.01)

Patent

CA 2120915

2120915 9308188 PCTABS00021 Tricyclic quinoxalinediones of formula (1), wherein X is alkyl, halogen, cyano, trifluoromethyl, nitro, hydroxy, amino, etc.; R1 is H, etc.; R2 is H, alkyl, cycloalkyl, alkenyl, alkynyl, cycloalkylalkyl, arylalkyl, substituted arylalkyl, aryl, or substituted aryl; W is H, CO2R3, CO2Y, CONR3R4, CONR3Y, CON(OR3)R4, COR3, CN, tetrazolyl, or substituted alkyl; R3 and R4 independently are H, alkyl, cycloalkyl, alkenyl, alkynyl, etc.; Y is mono-substituted alkyl or di-substituted alkyl; and n is an integer 0 or 1, or a pharmaceutically acceptable salt thereof, which are useful as a selective antagonist of glutamate receptor for the treatment or prevention of various diseases in animals including human being, for example, minimizing damage of central nervous system induced by ischaemic or hypoxylic conditions, treatment and/or prevention of neurodegenerative disorders, and further analgesics, antidepressants, anxiolitics, and anti-schizophrenics.

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