C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 491/20 (2006.01) C07D 498/22 (2006.01) C07D 513/22 (2006.01)
Patent
CA 2666136
This invention is directed to tricyclic spiro-oxindole derivatives of formula (I), wherein j, k, m, n, w, q, Y, Q, X, R1, R2 and R3 are as defined herein, as a stereoisomer, enantiomer, tautomer thereof or mixtures thereof; or a pharmaceutically acceptable salt, solvate or prodrug thereof, which are useful for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain. Pharmaceutical compositions comprising the compounds and methods of preparing and using the compounds are also disclosed.
L'invention concerne des dérivés spiro-oxindole tricycliques représentés par la formule (I) dans laquelle k, m, n, w, q, Y, Q, X, R1, R2 et R3 sont tels que définis dans les spécifications, sous forme de stéréoisomère, énantiomère, tautomère de ces dérivés ou de mélange de ceux-ci, ou un sel, un solvate ou un promédicament de ces composés pharmaceutiquement acceptable, qui conviennent pour le traitement et/ou la prévention des maladies et des troubles induits par le canal sodique, tels que la douleur. L'invention concerne aussi des compositions pharmaceutiques comprenant ces composés et des procédés de préparation et d'utilisation de ces composés.
Chafeev Mikhail
Chowdhury Sultan
Fu Jian-Min
Kamboj Rajender
Gowling Lafleur Henderson Llp
Xenon Pharmaceuticals Inc.
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