C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/04 (2006.01) A61K 31/4545 (2006.01) A61P 35/00 (2006.01) C07D 401/14 (2006.01) C07D 413/14 (2006.01) C07D 211/96 (2006.01) C07D 221/16 (2006.01)
Patent
CA 2293358
Novel tricyclic sulfonamide compounds of formula (1.0) and pharmaceutical compositions are disclosed which are inhibitors of the enzyme, farnesyl protein transferase. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering the novel sulfonamide compound to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammal such as a human.
La présente invention concerne des nouveaux composés tricycliques sulfonamides de la formule (1.0) et des compositions pharmaceutiquement acceptables, lesquels constituent des inhibiteurs de l'enzyme farnésyle transférase. La présente invention concerne également un procédé d'inhibition de la fonction Ras et donc d'inhibition de la croissance anormale des cellules. Le procédé consiste à administrer le nouveau composé sulfonamide à un système biologique. Ce procédé inhibe, en particulier, la croissance anormale des cellules chez un mammifère tel que l'homme.
Doll Ronald J.
Girijavallabhan Viyyoor M.
Njoroge F. George
Taveras Arthur G.
Vibulbhan Bancha
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Schering Corporation
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