Tricyclic sulfonamide matrix metalloproteinase inhibitors

Details Tricyclic sulfonamide matrix metalloproteinase inhibitors Tricyclic sulfonamide matrix metalloproteinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 417/12 (2006.01) A61K 31/5377 (2006.01) A61K 31/541 (2006.01) A61P 19/02 (2006.01) A61P 19/10 (2006.01) C07D 407/12 (2006.01)

Patent

CA 2371487

-42- Matrix metalloproteinase inhibitors are tricyclicsulfonamides of the Formula I Image or a pharmaceutically acceptable salt thereof, wherein R1 and R2 include hydrogen, alkyl, and substituted alkyl; R3 is OH or NHOH; X is O or S(O)n; n is 0, 1, or 2; p is 0, 1, 2, or 3; ~ is absent or a bond; and the sulfur atom bearing (0)q is bonded to the benzo ring at position a or position b.

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