Tricyclic triazolobenzazepine derivatives, process for...

Details Tricyclic triazolobenzazepine derivatives, process for... Tricyclic triazolobenzazepine derivatives, process for...

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/55 (2006.01) C07C 59/76 (2006.01) C07C 59/90 (2006.01) C07C 69/738 (2006.01) C07C 205/56 (2006.01) C07C 229/22 (2006.01) C07D 249/04 (2006.01) C07F 9/09 (2006.01) C07F 9/6561 (2006.01)

Patent

CA 2305307

Tricyclic triazolobenzazepine derivatives in the form of a prodrug. The compounds are ones represented by general formula (I) and pharmacologically acceptable salts and solvates thereof. They are useful as an antiallergic and have excellent bioavailability. In formula (I), R1 represents hydrogen, OH, alkyl, or phenylalkyl; R2, R3, R4, and R5 each represents hydrogen, halogeno, optionally protected hydroxyl, formyl, optionally substituted alkyl, alkenyl, alkoxy, etc.; and Q represents a group selected among groups (i) to (iv), halogeno, or alkoxy.

L'invention concerne des dérivés de triazolobenzazepine tricyclique sous la forme d'un promédicament. L'invention concerne également des composés représentés par la formule générale (I), ainsi que leurs sels et leurs solvates acceptables sur le plan pharmacologique. Ces composés sont utiles en tant qu'antiallergiques et présentent une excellente biodisponibilité. Dans la formule, R<1> représente hydrogène, OH, alkyle ou phénylalkyle; R<2>, R<3>, R<4> et R<5> représentent chacun hydrogène, halogéno, hydroxyle éventuellement protégé, formyle, alkyle éventuellement substitué, alcényle, alcoxy, etc.; et Q représente un groupe sélectionné parmi les groupes (i) à (iv), halogéno ou alcoxy.

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