Tricyclic vasopressin agonists

Details Tricyclic vasopressin agonists Tricyclic vasopressin agonists

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/55 (2006.01) C07D 498/04 (2006.01)

Patent

CA 2297407

The present invention provides compounds of general formula (I): wherein W is O or NH, optionally substituted, as well as methods and pharmaceutical compositions utilising these compounds for the treatment of disorder which may be remedied or alleviated by vasopressin agonist activity, including diabetes insipidus, nocturnal enuresis, nocturia, urinary incontinence, bleeding and coagulation disorders, or temporary delay of urination.

la présente invention concerne des composés représentés par la formule générale (I) dans laquelle W représente O ou NH, éventuellement substitué. La présente invention concerne également des procédés et des compositions pharmaceutiques utilisant ces composés pour le traitement d'un trouble qui peut être corrigé ou soulagé par une activité antagoniste de la vasopressine notamment le diabète insipide, l'énurésie nocturne, la nycturie, l'incontinence urinaire, les saignements et les troubles de la coagulation ou un retard temporaire de la miction.

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