C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/07 (2010.01) A61F 2/02 (2006.01) A61L 27/00 (2006.01) A61L 27/38 (2006.01) A61L 27/56 (2006.01) C08L 29/04 (2006.01) C12N 5/00 (2006.01) A61K 35/12 (2006.01)
Patent
CA 2445110
The present invention relates to a biocompatible support structure for culturing cells in three dimensions. In a preferred embodiment, the support structure is constituted essentially of cross-linked polyvinylalcohol (PVA). More preferably, the matrix has the form of a sponge and is used for the culture of hepatocytes. The invention also relates to methods of manufacturing such structure and to methods of using the same in vitro, ex vivo as well as in vivo. The invention further relates to a bioartificial organ and to a tridimensional cell culture system which may be used for the production of therapeutic proteins, used as a detoxification device, used as a tool in predictive toxicology of compounds in the pharmaceutical industry and/or used for transplantation.
L'invention concerne une structure support biocompatible pour la culture de cellules en trois dimensions. Dans un mode de réalisation préféré, cette structure support est constituée essentiellement de polyvinylalcool (PVA) réticulé. Mieux encore, la matrice, sous forme d'éponge, est utilisée pour la culture d'hépatocytes. La présente invention porte également sur des procédés pour réaliser ladite structure et pour l'utiliser in vitro, ex vivo et in vivo. Cette invention concerne aussi un organe bioartificiel et un système de culture de cellules en trois dimensions, lequel peut s'avèrer utile dans la production de protéines thérapeutiques en tant que dispositif de détoxication, qu'outil de toxicologie prédictive de composés dans l'industrie pharmaceutique et/ou pour les transplantations.
Denizeau Francine
Luna Saavedra Yascara Grisel
Mateescu Mircea-Alexandru
Robic
Transfert Plus Societe En Commandite
Universite Du Quebec A. Montreal
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