Trifluoromethyl derivatives of 1'-halogenobenzyl- spiro...

Details Trifluoromethyl derivatives of 1'-halogenobenzyl- spiro... Trifluoromethyl derivatives of 1'-halogenobenzyl- spiro...

C - Chemistry, Metallurgy

07

D

260/305.3

C07D 487/10 (2006.01)

Patent

CA 1201124

ABSTRACT OF THE DISCLOSURE FLUOROALKYL DERIVATIVES The invention concerns novel trifluoromethyl derivatives of 1'-hal- ogenobenzyl-spiro[imidazolidine-4,3'-indoline]-2,2',5-trione (I), their pharma- ceutically acceptable salts, and non-toxic, biodegradable precursors thereof. The derivatives are potent inhibitors of the enzyme aldose reductase and are use- ful in treating or preventing certain complications of diabetes. The invention also provides pharmaceutical compositions and processes for the manufacture of the derivatives. These compounds have the general formula Image in which the CF3 group is in the 5, 6 or 7 position and Ra, Rb and Rc are chosen from various combinations of hydrogen and halogen.

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