C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
167/100, 260/308
C07C 323/60 (2006.01) A61K 31/195 (2006.01) A61K 31/395 (2006.01) A61K 38/05 (2006.01) C07C 327/32 (2006.01) C07D 207/337 (2006.01) C07D 209/20 (2006.01) C07D 209/44 (2006.01) C07D 213/56 (2006.01) C07D 213/59 (2006.01) C07D 213/79 (2006.01) C07D 231/56 (2006.01) C07D 257/04 (2006.01) C07D 307/81 (2006.01) C07D 403/06 (2006.01) C07D 405/06 (2006.01) C07K 5/06 (2006.01) C07K 5/062 (2006.01)
Patent
CA 2038379
In accordance with the present invention, novel neutral endopeptidase inhibitors and methods for their use are disclosed. Compounds of the present invention, useful, for example, as cardio- vascular agents, have the general formula (see formula I) wherein X is (see formula II or III) Y can be -COR2, (see formula IV) phenyl, phenyl substituted with alkyl of 1 to 4 carbons, alkoxy of 1 to 4 carbons, alkylthio of 1 to 4 carbons, hydroxy, halo, nitro or trifluoromethyl, or a heterocyclic group selected from thiazolyl, 4,5-dihydrothiazolyl, pyridyl, oxazolyl, isoxazolyl, imidazolyl, tetrazolyl, benzimidazolyl, benzo- thiazolyl or benzoxazolyl including substituted heterocyclic groups wherein the substituents are selected from halo, alkyl and phenyl; Z can be (see formula V, VI, VII, VIII, XI or X) and wherein the various groups are as defined herein.
Delaney Norma G.
Loots Melanie
Rovnyak George C.
Delaney Norma G.
E. R. Squibb & Sons Inc.
Loots Melanie
Osler Hoskin & Harcourt Llp
Rovnyak George C.
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