Triglycerides and ethyl esters of phenylalkanoic acid and...

C - Chemistry – Metallurgy – 07 – C

Patent

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Details

C07C 69/612 (2006.01) A61K 31/215 (2006.01) C07C 57/30 (2006.01) C07C 69/618 (2006.01)

Patent

CA 2212047

Two new forms of prodrug for phenylacetate, of even congeners of phenylalkanoic acid and phenylalkenoic acids, which are the phenylalkanoic or phenylalkenoic esters of glycerol, or the ethyl esters of phenylalkanoic acid or phenylalkenoic acids. These forms of the drugs provide a convenient dosage form of the drugs. The prodrugs of the invention are useful to treat patients with diseases of nitrogen accumulation, patients with certain .beta.-hemoglobinopathies, anemia, and cancer.

L'invention concerne deux nouvelles formes de précurseurs de médicaments pour le phénylacétate, de congénères pairs d'acides phénylalcanoïques et phénylalcénoïques, qui sont les esters de glycérol ou d'esters éthyliques phénylalcanoïque ou phénylalcénoïques. Ces formes de médicaments constituent des formes galéniques avantageuses pour ces derniers. Les précurseurs de l'invention sont utiles pour traiter les patients atteints de troubles associés à une accumulation d'azote et les patients atteints de certaines .beta.-hémoglobinopathies, d'anémie et de cancer.

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