Trihydrochloride forms of a dihydropteridinone derivative...

Details Trihydrochloride forms of a dihydropteridinone derivative... Trihydrochloride forms of a dihydropteridinone derivative...

C - Chemistry, Metallurgy

07

D

C07D 475/00 (2006.01) A61K 31/19 (2006.01)

Patent

CA 2635834

The present invention relates to a specific salt of a dihydropteridione derivative, namely the trihydrochloride salt of the compound N-[trans-4-[4- (cyclopropylmethyl)-1- piperazinyl]cyclohexyl]-4-[[(7R)-7-ethyl-5,6,7,8- tetrahydro-5-methyl-8-(1-methylethyl)-6- oxo-2-pteridinyl]amino]-3-methoxy- benzamide, to its crystallisation in the form of an hydrate with water, to a process for the manufacture thereof, and to the use thereof in a pharmaceutical composition.

L'invention porte: sur un sel spécifique d'un dérivé de dihydroptéridione c.-à-d. un sel de trihydrochlorure du composé: compound N-[trans-4-[4-(cyclopropylméthyl)-1- piperazinyl]cyclohéxyl]-4-[[(7R)-7-éthyl-5,6,7,8-tétrahydro-5-méthyl-8-(1-méthyléthyl)-6- oxo-2-ptéridinyl]amino]-3-méthoxy-benzamide; sur sa cristallisation sous la forme d'hydrate et d'eau; sur son procédé de fabrication, et sur son utilisation dans des préparations pharmaceutiques.

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