C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 69/732 (2006.01) A61K 31/557 (2006.01) A61P 29/00 (2006.01) C07F 7/18 (2006.01)
Patent
CA 2603371
The invention features methods for the preparation of naturally occurring trihydroxy polyunsaturated eicosanoids and their structural analogs. The invention further provides new derivatives and analogs of trihydroxy polyunsaturated eicosanoids that can be prepared according to these methods. The invention also provides compositions and methods using trihydroxy polyunsaturated eicosanoid derivatives for the prevention, amelioration and treatment of a variety of diseases or conditions associated with inflammation or inflammatory response, autoimmune diseases, rheumatoid arthritis, cardiovascular diseases, or abnormal cell proliferation or cancer.
La présente invention a trait à des procédés pour la préparation d'éicosanoïdes polyinsaturés de trihydroxy d'origine naturelle et leurs analogues structurels. L'invention a également trait à de nouveaux dérivés et analogue d'éicosanoïdes polyinsaturés de trihydroxy qui peuvent être préparés selon ces procédés. L'invention a trait en outre à des compositions et des procédés mettant en oeuvre des dérivés d'éicosanoïdes polyinsaturés de trihydroxy pour la prévention, l'amélioration et le traitement de diverses maladies ou conditions liées à l'inflammation ou la réponse inflammatoire, des maladies auto-immunes, la polyarthrite rhumatoïde, des maladies cardio-vasculaires, ou la prolifération cellulaire anormale ou le cancer.
Riches Mckenzie & Herbert Llp
University Of Southern California
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