Triiodated isophthalamide x-ray contrast agents

Details Triiodated isophthalamide x-ray contrast agents Triiodated isophthalamide x-ray contrast agents

C - Chemistry, Metallurgy

07

D

167/36, 260/550.

C07D 209/48 (2006.01)

Patent

CA 1129438

ABSTRACT The invention provides a compound of the general formula Image (I) in which X represents an unsubstituted or substituted lower alkylene radical, R represents a hydrogen atom or a lower alkyl radical, R represents a hydrogen atom, a lower alkyl radical or a lower mono- or poly- hydroxyalkyl radical, R3 represents a hydrogen atom, a lower alkyl radi- cal or a lower mono- or poly- hydroxyalkyl radical, R4 represents a hydrogen atom, a lower alkyl radical or a lower mono- or poly- hydroxyalkyl radical, R5 represents a lower mono- or poly-hydroxyalkyl radical, R6 represents a hydrogen atom, a lower alkyl radi- cal or a lower mono- or poly- hydroxyalkyl radical, R7 represents a lower mono- or poly-hydroxyalkyl radical, salts thereof, processes for their preparation and use as X-ray contrast agents. Preferred salts are those with contrast agent acids. These salts are stable and excellently tolerable. Their solutions have low viscos- ity and therefore highly concentrated but nevertheless readily injectable X-ray contrast agent solutions can be manufactured.

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