Trimeric binding proteins for trimeric cytokines

Details Trimeric binding proteins for trimeric cytokines Trimeric binding proteins for trimeric cytokines

C - Chemistry, Metallurgy

07

K

C07K 14/52 (2006.01) A61K 38/19 (2006.01) A61P 29/00 (2006.01) C07K 14/525 (2006.01) C07K 14/715 (2006.01) C07K 14/725 (2006.01) C07K 16/24 (2006.01) C12N 5/10 (2006.01) C12N 5/28 (2006.01) C12N 15/10 (2006.01) C12N 15/62 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2503697

The present invention pertains to the provision of trimeric binding units which bind to trimeric cytokines. In particular there is provided a trimeric polypeptide comprising a trimerising domain and three monomers with binding members capable of binding a trimeric cytokine. Preferably , the trimeric binding units bind in a manner such that upon binding, all receptor binding sites of the trimeric cytokine are substantially blocked, and hence the potential biological activity of the trimeric cytokine is suppressed. In one aspect the invention relates to trimeric binders capable of binding to trimeric cytokines of the Tumor necrosis factor ligand superfamily, such as TNF, TRAIL, RANKL, TWEAK, APRIL and BAFF.

La présente invention concerne des unités de liaison trimériques qui se lient aux cytokines trimériques et plus particulièrement un polypeptide trimérique comprenant un domaine de trimérisation et trois monomères comprenant des éléments de liaison capables de lier une cytokine trimérique. De préférence, les unités de liaison trimériques se lient d'une manière telle que, lors de la liaison, tous les sites de liaison du récepteur de la cytokine trimérique sont sensiblement bloqués et par conséquent, l'activité biologique potentielle de la cytokine trimérique est supprimée. Un aspect de la présente invention concerne des liants trimériques qui sont capables de se lier à des cytokines trimériques appartenant à la superfamille des ligands du facteur de nécrose des tumeurs, tel que TNF, TRAIL, RANKL, TWEAK, APRIL et BAFF.

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