Trimeric hiv fusion inhibitors for treating or preventing...

Details Trimeric hiv fusion inhibitors for treating or preventing... Trimeric hiv fusion inhibitors for treating or preventing...

A - Human Necessities

61

K

A61K 38/17 (2006.01) A61P 31/18 (2006.01)

Patent

CA 2751865

Disclosed herein are trimeric polypeptide pharmaceutical compositions comprising three monomers, each monomer comprising a polypeptide having the amino acid sequence of the N- terminal heptad repeat (NHR or HR1) or C-terminal heptad repeat (CHR or HR2) of the transmembrane glycoprotein of human immunodeficiency virus (HIV) and a trimerization motif.

La présente invention concerne des compositions pharmaceutiques à base de polypeptides trimères comprenant trois monomères, chaque monomère comprenant un polypeptide ayant la séquence d'acides aminés de l'unité de répétition heptade de l'extrémité N-terminale (NHR ou HR1) ou de l'unité de répétition heptade de l'extrémité C-terminale (CHR ou HR2) de la glycoprotéine transmembranaire du virus de l'immunodéficience humaine (VIH) et un motif de trimérisation.

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