Trimeric il-1ra

Details Trimeric il-1ra Trimeric il-1ra

C - Chemistry, Metallurgy

07

K

C07K 14/47 (2006.01) C07K 14/545 (2006.01)

Patent

CA 2701705

Interleuekin-1 receptor antagonists (IL-1Ra) including fusion proteins having a trimerizing domain and an IL-1Ra polypeptide sequence. The fusion proteins are part of trimeric complexes that are used in pharmaceutical compositions for treating diseases mediated by IL-1. Effective treatment of inflammatory diseases, such as rheumatoid arthritis and diabetes, are described.

L'invention concerne des antagonistes du récepteur d'interleukine 1 (IL-1Ra) comprenant des protéines de fusion possédant un domaine de trimérisation et une séquence de polypeptide IL-1Ra. Les protéines de fusion font partie de complexes trimériques qui sont utilisés dans des compositions pharmaceutiques pour traiter des maladies provoquées par IL-1. Des traitements efficaces de maladies inflammatoires comme l'arthrite rhumatoïde et les diabètes sont décrits.

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