Trimeric ox40-immunoglobulin fusion protein and methods of use

Details Trimeric ox40-immunoglobulin fusion protein and methods of use Trimeric ox40-immunoglobulin fusion protein and methods of use

C - Chemistry, Metallurgy

07

K

C07K 19/00 (2006.01) A61K 38/16 (2006.01) A61K 48/00 (2006.01) A61P 37/02 (2006.01) C07K 14/525 (2006.01) C07K 16/00 (2006.01) C12N 15/62 (2006.01) C07K 14/715 (2006.01) C12N 15/85 (2006.01)

Patent

CA 2606809

Compositions including a trimeric OX-40 fusion protein are disclosed. Also disclosed are methods for enhancing the immune response of a mammal to an antigen by engaging the OX-40 receptor on the surface of T-cells involving administering to the mammal a composition comprising a trimeric OX-40 fusion protein and a pharmaceutically acceptable carrier.

La présente invention concerne des compositions incluant une protéine de fusion OX-40 trimère. L'invention concerne également des procédés permettant de renforcer la réponse immunitaire d'un mammifère à un antigène en engageant le récepteur OX-40 sur la surface des lymphocytes T par administration au mammifère concerné d'une composition comprenant une protéine de fusion OX-40 trimère et un vecteur pharmaceutiquement admis.

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