Tripeptide and tetrapeptide thioethers

Details Tripeptide and tetrapeptide thioethers Tripeptide and tetrapeptide thioethers

C - Chemistry, Metallurgy

12

P

C12P 21/02 (2006.01) A61K 38/06 (2006.01) A61P 31/00 (2006.01) C07K 5/08 (2006.01)

Patent

CA 2587284

Tripeptide and tetrapeptide thioethers, pharmaceutical compositions containing them, their pharmaceutical use, and their preparation. The compounds are useful in potentiating the cytotoxic effects of chemotherapeutic agents in tumor cells, selectively exerting toxicity in tumor cells, elevating the production of GM progenitors in bone marrow, stimulating the differentiation of bone marrow, mitigating the myelosuppressive effects of chemotherapeutic agents, and modulating hematopoiesis in bone marrow.

La présente invention concerne des thioéthers de tripeptides et de tétrapeptides, des compositions pharmaceutiques les contenant, leur utilisation pharmaceutique et leur préparation. Les composés sont utiles pour potentialiser les effets cytotoxiques d~agents chimiothérapiques dans les cellules tumorales, en exerçant sélectivement une toxicité dans les cellules tumorales, en augmentant la production des progéniteurs GM dans la moelle osseuse, en stimulant la différentiation de la moelle osseuse, en atténuant les effets myélosuppresseurs des agents chimiothérapiques, et en modulant l~hématopoïèse de la moelle osseuse.

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