Tripeptide derivatives

Details Tripeptide derivatives Tripeptide derivatives

C - Chemistry, Metallurgy

07

K

530/5.08

C07K 5/08 (2006.01) C07K 5/02 (2006.01) C07K 5/068 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1318461

- 1 - Abstract of the Disclosure A tripeptide derivative represented by the following formula Image (I) wherein R1 represents a C1-10 alkyl group, a C4-7 cycloalkyl or C5-7 cycloalkyl-lower alkyl group, a phenyl or phenyl-lower alkyl group in which the benzene ring may optionally be sub- stituted by a substituent selected from halogen, lower alkyl, lower alkoxy, phenyl, methylenedi- oxy, ethylenedioxy, amino, di(lower alkyl)amino and hydroxy, a naphthyl or naphtbyl-lower alkyl group in which the naphthalene ring may option- ally be substituted by a substituent selected from halogen, lower alkyl, lower alkoxy and hydroxy, a heterocyclic or heterocyclic-lower alkyl group in which the heterocycle is a saturated or unsaturated 5- or 6-membered ring containing a nitrogen, oxygen or sulfur atom as the hetero atom, and may optionally be substi- tuted by a substituent selected from halogen, lower alkyl, lower alkoxy, amino, di(lower alkyl)amino, hydroxy, oxo and saturated 5- or 6-membered nitrogen-containing heterocyclic group, and further may optionally be fused to a benzene ring, or an imidazolylvinyl group; R2 represents a hydrogen atom, a C1-10 alkyl group or a benzyl group; R3 represents a group of the formula - 2 - Image or -?-?H-COOR4 (a) (b) in which Image represents a benzene, cyclo- pentane or cyclohexane ring, R4 represents a hydrogen atom, a C1-10 alkyl group or a benzyl group, p is n or 1, q is 1, 21 or 3, and X represents a phenyl group which may optionally be substituted by a substi- tuent selected from halogen, lower alkoxy and hydroxy, a C4-8 cycloalkyl group, or a C5-7 cycloalkyl group which is fused to a benzene, and Y represents a hydrogen atom or a lower alkyl group, or X and Y, to- gether with the nitrogen and carbon atoms to which they are bonded, forms a 5- or 6-membered heterocycle which may contain a nitrogen, oxygen or sulfur atom, W represents a single bond, -O- or -NH-, T represents a single bond, -?- or -S-, and m is 2 or 3, or salts thereof; processes for production thereof; and the use thereof as a medicine, particularly an anti- hypertensive agent.

536368

Affiliated with

Also associated with

Rating

Tripeptide derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Tripeptide derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Tripeptide derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1219268