Tripeptides and derivatives thereof for cosmetic application...

Details Tripeptides and derivatives thereof for cosmetic application... Tripeptides and derivatives thereof for cosmetic application...

C - Chemistry, Metallurgy

07

K

C07K 5/09 (2006.01) A61K 8/64 (2006.01) A61Q 19/08 (2006.01) C07K 5/00 (2006.01)

Patent

CA 2525476

The invention relates to compounds and to the cosmetically acceptable salts thereof, which correspond to general formula (I), wherein: R1 represents H, - C(O)-R6, -SO2-R6 or -C(O)-XR6; R2 and R4, independent of one another, represent (CH2)n-NH2 or (CH2) 3-NHC(NH)NH2; n equals 1 4; R3 represents linear or branched C1-C4 alkyl that is optionally substituted by hydroxy; R5 and R6, independent of one another, represent hydrogen, optionally substituted (C1- C24) alkyl, optionally substituted C2-C24 alkenyl, optionally substituted phenyl, optionally substituted phenyl-C1-C4 alkyl or 9-fluorenylmethyl; X represents oxygen (-O-) or -NH-; or XR5 with X = O also represents the esters of a-tocopherol, tocotrienol or retinol, with the provision that R1 and R5 do not represent hydrogen and X does not represent oxygen at the same time. The invention also relates to the production of the compounds of general formula (I) and to a cosmetically active composition that contains at least one compound of formula (I).

La présente invention concerne des composés et leurs sels acceptables d'un point de vue cosmétique, de formule générale (I) dans laquelle R?1¿ = H, -C (0) -R?6¿, -S0¿2?-R?6¿ ou -C (0) -XR?6¿, R?2¿ et R?4¿ = indépendamment l'un de l'autre (CH¿2?)¿n? -NH¿2? ou (CH¿2?) ¿3??-¿-NHC (NH) NH¿2?, n = 1-4, R?3¿ = alkyle C¿1?-C¿4? linéaire ou ramifié, éventuellement substitué par hydroxy, R?5¿ et R?6¿ = indépendamment l'un de l'autre hydrogène, alkyle (C¿1?-C¿24?) éventuellement substitué, alcényle C¿2?-C¿24? éventuellement substitué, phényle éventuellement substitué, phényl-C¿1?-C¿4?-alkyle éventuellement substitué ou 9-fluorénylméthyle, X = oxygène (-O-) ou -NH-; ou XR?5¿ avec X = O, les esters d'a-tocophérol, tocotriénol ou rétinol, sous réserve que R?1 ¿et R?5¿ ne représentent pas en même temps hydrogène et X oxygène. La présente invention concerne également la production de ces composés de formule générale (I), ainsi que des préparations cosmétiques qui contiennent au moins un composé de formule (I).

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