C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 317/50 (2006.01) A61K 31/135 (2006.01) A61K 31/22 (2006.01) A61K 31/33 (2006.01) C07C 217/04 (2006.01) C07C 217/18 (2006.01) C07C 217/30 (2006.01) C07C 217/34 (2006.01) C07C 217/42 (2006.01) C07C 219/06 (2006.01) C07C 251/32 (2006.01) C07C 251/48 (2006.01) C07C 251/60 (2006.01) C07D 295/088 (2006.01) C07D 295/092 (2006.01) C07D 311/58 (2006.01) C07D 317/54 (2006.01) C07D 335/06 (2006.01) C07D 405/12 (2006.01) C07F 9/12 (2006.01) C07F 9/547 (2006.01) C07F 9/655 (2006.01) C07F 9/6558 (2006.01)
Patent
CA 2109426
ABSTRACT OF THE DISCLOSURE This invention is directed to a triphenylalkene derivative represented by the following general formula (1) or a pharmaceutically acceptable acid addition salt thereof, and it provides a pharmaceutical composition, which possesses a tumor inhibition function and also has osteoporosis curing activity: Image (2) Image (1) Image (3) Image (4) wherein R1 is selected from the formulae (2), (3) and (4), R6 and R7 is a hydrogen atom, an alkyl group or a cycloalkyl group, or forms a heterocyclic group together with the adjoining nitrogen atom (but R6 and R7 are not hydrogen atoms at the same time); R8 represents a hydrogen atom or an alkylcarbonyl group; R2 represents an alkyl group or a cycloalkyl group; R3 represents a 3,4-methylenedioxylphenyl group: R4 represents a hydrogen atom, a hydroxyl group, R9C(O)O-, R10OCH2O-, OPO(OH)2 or CH=NOR11; R9 represents an alkyl group and R10 represents an alkyl group or an alkylcarbonyl group; R5 represents a hydrogen atom or CH=NOR11; and R11 represents a hydrogen atom, an alkyl group, a substituted alkyl group.
Ando Satoshi
Kouji Hiroyuki
Asahi Kasei Kogyo Kabushiki Kaisha
Goudreau Gage Dubuc
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