Triphenylethylenes, process for their production,...

Details Triphenylethylenes, process for their production,... Triphenylethylenes, process for their production,...

C - Chemistry, Metallurgy

07

C

C07C 317/44 (2006.01) A61K 31/10 (2006.01) A61K 31/13 (2006.01) A61K 31/16 (2006.01) A61K 31/34 (2006.01) A61K 31/38 (2006.01) A61K 31/395 (2006.01) A61K 31/44 (2006.01) C07C 317/18 (2006.01) C07C 317/28 (2006.01) C07C 323/12 (2006.01) C07C 323/25 (2006.01) C07C 323/60 (2006.01) C07D 207/333 (2006.01) C07D 213/32 (2006.01) C07D 213/34 (2006.01) C07D 233/64 (2006.01) C07D 237/08 (2006.01) C07D 239/26 (2006.01) C07D 241/12 (2006.01) C07D 295/185 (2006.01) C07D 307/42 (2006.01) C07D 333/18 (2006.01)

Patent

CA 2226469

New triphenyl ethylenes have the general formula (I), in which n is an integer from 1 to 10, R' is a sulphur-containing organic rest, R'' is a hydrogen atom, an iodine atom or a hydroxyl group, E is a hydrogen atom, G is a hydrogen atom, or E and G form together a methylene bridge. These new compounds have strong anti-oestrogenic properties and are suitable for producing medicaments, for example for treating mammary carcinoma.

L'invention concerne des éthylènes de triphényle de formule générale (I), dans laquelle n est un nombre entier de 1 à 10, R' est un reste organique contenant du soufre, R'' est un atome d'hydrogène, un atome d'iode ou un groupe hydroxyle, E est un atome d'hydrogène, G est un atome d'hydrogène, ou E et G forment ensemble un pont méthylène. Ces nouveaux composés ont de fortes propriétés anti-oestrogéniques et permettent de produire des médicaments, par exemple pour la thérapie du carcinome mammaire.

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