Triple reuptake inhibitors and methods of their use

Details Triple reuptake inhibitors and methods of their use Triple reuptake inhibitors and methods of their use

C - Chemistry, Metallurgy

07

D

C07D 209/08 (2006.01) A61K 31/403 (2006.01) A61P 25/00 (2006.01) C07D 209/52 (2006.01)

Patent

CA 2746055

Provided herein are bicyclic compounds and methods of synthesis thereof. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders. Compounds provided herein inhibit reuptake of endogenous monoamines, such as dopamine, serotonin and norepinephrine (e.g., from the synaptic cleft) and modulate one or more monoamine transporter. Pharmaceutical formulations containing the compounds are also provided.

La présente invention concerne des composés bicycliques et leurs méthodes de synthèse. Les composés selon l'invention peuvent être employés dans le traitement prophylactique ou thérapeutique et/ou la gestion de divers troubles neurologiques. Les composés selon l'invention inhibent la recapture de monoamines endogènes, comme la dopamine, la sérotonine et la norépinéphrine (par exemple à partir de la fente synaptique) et modulent un ou plusieurs transporteurs de type monoamine. La présente invention concerne également des formules pharmaceutiques contenant lesdits composés.

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