A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 36/37 (2006.01) A61K 31/58 (2006.01) A61P 29/00 (2006.01) A61P 37/06 (2006.01)
Patent
CA 2658989
The present invention provides for the use of Tripterygium Wilfordii Hook F extracts and purified components thereof in the treatment of inflammation or an immune disorder with concomitant lack of steroidal effect. Extracts of this plant (T2) bound to the glucocorticoid receptor and competitively inhibited glucocorticoid mediated cellular processes, such as dexamethasone binding to the glucocorticoid receptor, glucocorticoid mediated activation of target genes, dexamethasone dependent cellular growth, with concomitant inhibition of cyclooxygenase-2 induction and inflammatory processes such as the production of prostaglandin E2. The T2 extract components triptolide and tripdiolide were effective inhibitors. The particular advantage provided by the methods herein is the treatment or prevention of inflammation and the concomitant lack of steroidal agonist effects and NSAID side effects. Conditions treatable by the present methods include inflammation and immune disorders including autoimmune disease.
Cai Jian
Kovacs William J.
Lipsky Peter E.
Olsen Nancy J.
Tao Xe-Lien
Board Of Regents The University Of Texas System
Cai Jian
Gowling Lafleur Henderson Llp
Vanderbilt University
LandOfFree
Tripterygium wilfordii preparations and uses thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Tripterygium wilfordii preparations and uses thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Tripterygium wilfordii preparations and uses thereof will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1559565