Triptolide derivatives for modulation of apoptosis and...

Details Triptolide derivatives for modulation of apoptosis and... Triptolide derivatives for modulation of apoptosis and...

C - Chemistry, Metallurgy

07

J

C07J 73/00 (2006.01) A61K 31/365 (2006.01) A61K 31/58 (2006.01) C07D 493/04 (2006.01) C07J 71/00 (2006.01)

Patent

CA 2485794

Variously substituted carbonate and carbamate derivatives of triptolide compounds have good aqueous solubility and convert to biologically active compounds in vivo, at a rate which can be modulated by varying the substitution on the prodrug. The prodrugs are useful as immunosuppressive, anti-inflammatory and anticancer agents.

Selon cette invention, des dérivés carbonate et carbamate différemment substitués de composés de triptolide possèdent une bonne solubilité dans l'eau et se convertissent en des composés actifs au niveau biologique in vivo, à une vitesse pouvant être modulée par variation de la substitution sur le promédicament. Ces promédicaments sont utiles en tant qu'agents immunosuppresseurs, anti-inflammatoires et anticancéreux.

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