Triptolide prodrugs having high aqueous solubility

Details Triptolide prodrugs having high aqueous solubility Triptolide prodrugs having high aqueous solubility

C - Chemistry, Metallurgy

07

D

C07D 493/22 (2006.01) A61K 31/336 (2006.01) A61K 31/343 (2006.01) A61K 31/365 (2006.01) A61P 35/00 (2006.01) A61P 37/06 (2006.01) C07D 307/77 (2006.01) C07D 407/14 (2006.01) C07D 493/20 (2006.01)

Patent

CA 2448775

Compounds useful in immunosuppressive, anti-inflammatory and anticancer treatment are described. The compounds are triptolide analogs with improved water solubility and generally lower toxicity and improved pharmacokinetics compared to the parent compound.

L'invention concerne des composés utilisés dans le traitement immunodépresseur, anti-inflammatoire et anticancéreux. Ces composés sont des analogues de triptolides caractérisés par une solubilité dans l'eau améliorée, une toxicité généralement plus faible, ainsi que par une phase pharmacocinétique améliorée par rapport au composé parent.

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