Trisubstituted 1,2,4-triazoles

Details Trisubstituted 1,2,4-triazoles Trisubstituted 1,2,4-triazoles

C - Chemistry, Metallurgy

07

D

C07D 401/04 (2006.01) A61K 31/4196 (2006.01) A61P 25/00 (2006.01)

Patent

CA 2697974

The present invention relates to substituted 1-(alkyl)-3-aniline-5-aryl triazole derivatives and analogues or pharmaceutically acceptable salts thereof, processes for preparing them, pharmaceutical compositions containing them and their use in therapy, according to Formula (I). The invention particularly relates to potent positive allosteric modulators of nicotinic acetylcholine receptors which have the capability of increasing the efficacyofnicotinic receptor agonists.

La présente invention porte sur des dérivés de 1-(alkyl)-3-aniline-5-aryltriazole substitués et sur leurs analogues ou sels pharmaceutiquement acceptables, sur des procédés permettant de les préparer, sur des compositions pharmaceutiques les contenant et sur leur utilisation en thérapie, selon la Formule (I). L'invention porte particulièrement sur des modulateurs allostériques positifs puissants de récepteurs nicotiniques à l'acétylcholine qui ont la capacité d'augmenter l'efficacité d'agonistes des récepteurs nicotiniques.

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