C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 251/58 (2006.01) A61K 31/15 (2006.01) A61K 31/33 (2006.01) C07D 295/088 (2006.01) C07D 295/108 (2006.01) C07D 317/58 (2006.01) C07D 405/12 (2006.01)
Patent
CA 2120990
TRISUBSTITUTED CYCLOALKANE DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF A b s t r a c t The invention relates to novel, pharmaceutically active trisubstituted cycloalkane derivatives, a process for the preparation thereof and pharmaceutical compositions comprising the same. The invention also encompasses the use of the said cycloalkane derivatives for the treatment of diseases and for the preparation of pharmaceutical com- positions suitable for the treatment of diseases. The compounds according to the invention are characterized by the general formula (I), Image (I) wherein R represents hydrogen, C1-4 alkyl or hydroxyl, R1 stands for C1-12 alkyl, R2 and R3 each represents hydrogen, C1-12 alkyl or C2-12 alkenyl, or R2 and R3 together with the adjacent nitrogen atom form a 4- to 7-membered ring optionally comprising an oxygen, - 2 - sulfur or a further nitrogen atom, which latter may carry a phenyl, benzyl or C1-4 alkyl substituent, R4 and R5 each stands for hydrogen, halogen or C1-4 alkoxy, or together represent a 3,4-methylenedioxy group, n is an integer from 2 to 5, A represents a valency bond or a -CH2- group. The compounds exert a valuable antiulcer effect, so they can be used to advantage in the therapy.
Bajnogel Judit
Blasko Gabor
Budai Zoltan
Egyed Andras
Fekete Marton
Egis Gyogyszergyar Rt.
Fetherstonhaugh & Co.
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