C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/202, 167/223
C07D 241/04 (2006.01) A61K 31/495 (2006.01) C07D 405/12 (2006.01) C07D 417/00 (2006.01) C07D 417/04 (2006.01) C07D 417/14 (2006.01) C07D 471/04 (2006.01)
Patent
CA 2002722
24205-854 Abstract of the Disclosure Novel trisubstituted piperazine compounds of the formula (I): (I) Image wherein A is an optionally substituted phenyl group, an optionally substituted condensed polycyclic hydrocarbon group, an optionally substituted hetero-cyclic group or a styryl group of the formula: Ar - CR4 = CR5 - wherein Ar is an optionally substituted phenyl group, and R4 and R5 are independently hydrogen or a lower alkyl group, X is methylene group, carbonyl group or thiocarbonyl group, G is a group of the formula: ?CH2?nZ-R6 wherein n is an integer of 0 to 2, Z is a chemical bond, O, S, SO, SO2, CO, COO, CONR7 or NR7 (wherein R7 is hydrogen, a lower alkyl group, a lower haloalkyl group, a lower alkenyl group or a lower alkoxycarbonyl group), and R6 is hydrogen a lower alkyl group, a lower haloalkyl group or a lower alkenyl group, provided that, when n is O and Z is chemical bond, R6 is not hydrogen or lower alkyl, and R1, R2 and R3 are independently a lower alkyl group, and salts thereof, are useful as a platelet activating factor antagonist.
Nishikawa Kohei
Sugihara Hirosada
Fetherstonhaugh & Co.
Nishikawa Kohei
Sugihara Hirosada
Takeda Chemical Industries Ltd.
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