C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 231/38 (2006.01) A61K 31/455 (2006.01) A61P 25/00 (2006.01) C07D 401/04 (2006.01) C07D 407/04 (2006.01) C07D 407/14 (2006.01)
Patent
CA 2722805
The present invention relates to 1-alkyl-3-aniline-5-aryl-pyrazole derivatives and pharmaceutically acceptable salts thereof, processes for preparing them, pharmaceutical compositions containing them and their use in therapy, according to Formu-la (I). The invention particularly relates to positive allosteric modulators of nicotinic acetylcholine receptors, such positive al-losteric modulator having the capability to increase the efficacy of nicotinic receptor agonists.
La présente invention concerne des dérivés 1-alkyl-3-anilino-5-aryl-pyrazoles et leurs sels pharmaceutiquement acceptables, des procédés pour les préparer, des compositions pharmaceutiques les contenant, et leur utilisation en thérapeutique, ces dérivés étant représentés par la formule (I). L'invention concerne en particulier des modulateurs allostériques positifs des récepteurs nicotiniques de l'acétylcholine, ces modulateurs allostériques positifs ayant la capacité d'augmenter l'efficacité des agonistes des récepteurs nicotiniques.
Macdonald Gregor James
Thuring Johannes Wilhelmus John F.
Zhuang Wei
Gowling Lafleur Henderson Llp
Janssen Pharmaceutica Nv
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