Trisubstituted quinazolinone derivatives as vanilloid...

C - Chemistry – Metallurgy – 07 – D

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C07D 239/95 (2006.01) A61K 31/517 (2006.01) A61P 29/00 (2006.01) C07D 239/91 (2006.01) C07D 401/04 (2006.01) C07D 403/04 (2006.01)

Patent

CA 2631438

The present invention relates to quinazolinone compounds of the formula wherein R2, R3, R5, R6 R7 and R8 are as defined in the specification and in the claims, in free form or in salt form, processes for their preparation and their use as pharmaceuticals, particularly in the treatment of disorders ameliorated by administration of TRPV1 antagonists.

La présente invention concerne des composés de quinazolinone répondant à la formule, R2, R3, R5, R6 R7 et R8 étant tels que définis dans la description et les revendications, présentés sous forme libre ou sous forme de sels, ainsi que des procédés pour leur préparation et leur utilisation en tant qu'agents pharmaceutiques, en particulier pour le traitement de troubles atténués par l'administration d'antagonistes de TRPV1.

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