Trisubstituted thiophenes as progesterone receptor modulators

C - Chemistry – Metallurgy – 07 – D

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Details

C07D 409/14 (2006.01) A61K 31/4535 (2006.01) C07D 333/36 (2006.01) C07D 409/04 (2006.01) C07D 491/10 (2006.01)

Patent

CA 2585337

The present invention is directed to novel trisubstituted thiophene derivatives, pharmaceutical compositions containing them and their use in the treatment or prevention of disorders and diseases mediated by agonists and antagonists of the progesterone receptor. The clinical usage of these compounds are related to hormonal contraception, the treatment and/or prevention of secondary dysmenorrhea, amenorrhea, dysfunctional uterine bleeding, uterine leiomyomata, endometriosis; polycystic ovary syndrome, carcinomas and adenocarcinomas of the endometrium, ovary, breast, colon or prostate. Additional uses of the invention include stimulation of food intake.

La présente invention porte sur de nouveaux dérivés de thiophènes substitués, sur des compositions pharmaceutiques les contenant et sur leur utilisation dans le traitement ou la prévention de troubles et de maladies induites par des agonistes et des antagonistes du récepteur de la progestérone. L'usage clinique de ces composés est en rapport avec la contraception hormonale, le traitement et/ou la prévention de la dysménorrhée secondaire, l'aménorrhée, la ménométrorragie, le léiomyome, l'endométriose; le syndrome des ovaires polykystiques, les carcinomes et les adénocarcinomes de l'endomètre, des ovaires, des seins, du côlon ou de la prostate. L'invention peut également s'appliquer à la stimulation de l'absorption de nourriture.

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