Trisubstituted thioxanthines

Details Trisubstituted thioxanthines Trisubstituted thioxanthines

C - Chemistry, Metallurgy

07

D

C07D 473/22 (2006.01) A61K 31/52 (2006.01) C07D 473/18 (2006.01) C07D 473/20 (2006.01) C07D 473/38 (2006.01)

Patent

CA 2206804

Disclosed are compounds of formula (I), wherein R1, R3 and R8 are independently alkyl, aryl or aralkyl, and R2 is selected from the group consisting of S and O, R6 is selected from the group consisting of S and O, provided that R2 and R6 are not both O. The compounds are effective PDE IV inhibitors and possess improved PDE IV inhibition and improved selectivity with regard to PDE III inhibition. Methods of treatment using the compounds are also disclosed.

On décrit des composés de la formule (I), où R<1>, R<3> et R<8> sont indépendamment alkyle, aryle ou aralkyle; R<2> est choisi dans le groupe qui comprend S et O, et R<6> est choisi dans le groupe qui comprend S et O, à condition que R<2> et R<6> ne soient pas O. Les composés sont des inhibiteurs efficaces de phosphodiestérases (PDE) IV et offrent à la fois une capacité d'inhibition améliorée des PDE IV et une sélectivité améliorée par rapport à l'inhibition des PDE III. On décrit également des méthodes de traitement qui reposent sur les composés en question.

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