Triterpene derivative and medicinal composition

Details Triterpene derivative and medicinal composition Triterpene derivative and medicinal composition

C - Chemistry, Metallurgy

07

J

C07J 63/00 (2006.01) A61K 31/56 (2006.01) C07J 71/00 (2006.01)

Patent

CA 2193679

Hederagenin derivatives represented by general formula (1) and pharmaceutically acceptable salts thereof, and a medicinal composition containing the same as the active ingredient and being efficacious in treating nephritis, wherein R1 represents OR11 or NR11R12, and R11 and R12 represent each independently hydrogen, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted aryl or optionally substituted heteroaryl; R2 and R3 represent each independently hydrogen, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted acyl, optionally substituted monoalkylcarbamoyl, optionally substituted dialkylcarbamoyl or optionally substituted alkoxycarbonyl, or alternatively R2 and R3 are combined together to represent carbonyl.

Dérivés de l'hédéragénine de formule générale (1), leurs sels pharmacocompatibles et préparation médicinale, dont ils constituent le principe actif, efficaces dans le traitement des néphrites. Dans la formule (1): R?1¿ représente OR?11¿ ou NR?11¿R?12¿, (R?11¿ et R?12¿ représentant chacun indépendamment hydrogène, alkyle éventuellement substitué, cycloalkyle éventuellement substitué, alcényle éventuellement substitué, alcynyle éventuellement substitué, aryle éventuellement substitué, hétéroaryle éventuellement substitué); R?2¿ et R?3¿ représentent chacun indépendamment hydrogène, alkyle éventuellement substitué, cycloalkyle éventuellement substitué, alcényle éventuellement substitué, alcynyle éventuellement substitué, acyle éventuellement substitué, monoalkylcarbamoyle éventuellement substitué, dialkylcarbamoyle ou alcoxycarbonyle éventuellement substitué; à moins que R?2¿ et R?3¿ ne se combinent ensemble pour représenter un carbonyle.

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