Triterpene derivatives and remedies for liver diseases

Details Triterpene derivatives and remedies for liver diseases Triterpene derivatives and remedies for liver diseases

C - Chemistry, Metallurgy

07

J

C07J 71/00 (2006.01) A61K 31/56 (2006.01) A61K 31/58 (2006.01) C07J 63/00 (2006.01)

Patent

CA 2247327

Triterpene derivatives efficacious in the treatment of liver diseases. The remedies contain as the active ingredient triterpene derivatives represented by general formula (I) or salts thereof: wherein R1 represents hydroxy, arylmethyloxy, lower alkoxy or lower alkanoyloxy; R2 represents lower alkyl, lower alkenyl, -CH2OR5, formyl, -COOR6 or -CH2N(R7)R8, or R1 and R2 may form together -O-C(R9)R10-O-CH2-; R3 and R4 are the same or different and each represents hydrogen, hydroxy, lower alkyl, lower alkenyl, aryl, hydroxymethyl, -N(R11)R12, formyl, -COOR6 or -OR13, or R3 and R4 may form together oxo, hydroxyimino or alkylidene; and X represents O, CH2 or NH.

L'invention a trait à des dérivés triterpéniques se révélant efficaces pour traiter des maladies hépatiques. Les remèdes selon l'invention contiennent comme ingrédient actif des dérivés triterpéniques répondant à la formule générale (I) ou leurs sels. Dans cette formule, R?1¿ représente un hydroxy, un arylméthyloxy, un alkoxy ou un alkanoyloxy de faibles poids moléculaires, R?2¿ représente un alkyl de faible poids moléculaire, un alcényle de faible poids moléculaire, -CH¿2?OR?5¿, un formyle, -COOR?6¿ ou -CH¿2?N(R?7¿)R?8¿, ou bien R?1¿ et R?2¿ peuvent former ensemble -O-C(R?9¿)R?10¿-O-CH¿2?, R?3¿ et R?4¿ sont identiques ou différents, chacun représentant un hydrogène, un hydroxy, un alkyl de faible poids moléculaire, un alcényle de faible poids moléculaire, un aryle, un hydroxyméthyle, -(NR?11¿)R?12¿, un formyle, -COOR?6¿ ou -OR?13¿, ou bien R?3¿ et R?4¿ peuvent former ensemble un oxo, un hydroxy-imino ou un alkylidène et X représente O, CH¿2? ou NH.

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