Trivalent, bispecific antibodies

Details Trivalent, bispecific antibodies Trivalent, bispecific antibodies

C - Chemistry, Metallurgy

07

K

C07K 16/00 (2006.01) C07K 16/46 (2006.01) A61K 39/395 (2006.01) C07K 14/71 (2006.01) C07K 16/28 (2006.01) C07K 16/32 (2006.01)

Patent

CA 2757931

The present invention relates to trivalent, bispecific antibodies, methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof. The trivalent, bispecific antibodies of the invention comprise a full length antibody specifically binding to a first antigen and consisting of two antibody heavy chains and two antibody light chains and a VH domain fused to the C-terminus of one of said heavy chains and a VL domain fused to the C-terminus of the other said heavy chains, wherein said VH domain and said VL domain together form an antigen-binding site specifically binding to a second antigen.

La présente invention concerne des anticorps trivalents bispécifiques, des procédés pour leur production, des compositions pharmaceutiques contenant lesdits anticorps et des utilisations de ceux-ci. Les anticorps trivalents bispécifiques de l'invention comprennent un anticorps de longueur totale se liant spécifiquement à un premier antigène et étant constitué de deux chaînes lourdes d'anticorps et deux chaînes légères d'anticorps et un domaine VH fusionné à la terminaison C d'une desdites chaînes lourdes et un domaine VL fusionné à la terminaison C de l'autre desdites chaînes lourdes, ledit domaine VH et ledit domaine VL formant conjointement un site de liaison d'antigène se liant spécifiquement à un deuxième antigène.

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