Trkb agonists for treating autoimmune disorders

Details Trkb agonists for treating autoimmune disorders Trkb agonists for treating autoimmune disorders

A - Human Necessities

61

K

A61K 38/18 (2006.01) A61P 25/16 (2006.01) A61P 25/28 (2006.01) A61P 37/00 (2006.01) C07K 16/18 (2006.01)

Patent

CA 2672750

Tyrosine receptor kinase (TrkB) agonists are provided for reducing leukocyte invasion of the central nervous system in autoimmune diseases such as multiple sclerosis. TrkB agonists include naturally-occurring agonists, such as NT4 and BDNF, as well as agonists such as agonist antibodies.

L'invention concerne des agonistes du récepteur tyrosine kinase (TrkB) destinés à réduire l'invasion des leucocytes du système nerveux central dans le cadre des maladies auto-immunes telles que la sclérose en plaques. Les agonistes de TrkB incluent les agonistes naturels, par exemple NT4 et BDNF, ainsi que les agonistes tels que les anticorps agonistes.

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