Trna binding domain

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 9/00 (2006.01) A61K 38/16 (2006.01) A61P 31/04 (2006.01) A61P 31/12 (2006.01) A61P 39/06 (2006.01) C07K 14/32 (2006.01) C07K 16/12 (2006.01) C12N 15/52 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2341765

There is disclosed a substantially pure peptide comprising the following sequence: [ML] -X(3) -[LIVMC] -X(3) -[GMNEHK] -[MLFYI] -X(2) -[ST] -X(3) - [SAIG] - [RMIK] -X(2) -[MIVA] -X(2) -[GNRHK] -X-[IVLF] -X-[LIV] -[NDSRGAL] - X(3) -[LIVSQ] -X(2) -[PILVTAC] wherein X represents any amino acid. Also disclosed is a method for determining whether a nucleic acid comprises a tRNA anticodon stem-loop. Another aspect comprises a method for identifying a substance which binds to a wherein the binding is detected by assaying for conjugates, for free substance, or for non-complexed peptide. Also described is a method of determining whether a test compound is an agonist or antagonist of a tRNA synthetase-tRNA anticodon stem-loop interaction or ribosomal S4 protein-tRNA anticodon stem-loop interaction. There is also described a method for obtaining a substantially pure nucleic acid comprising a tRNA anticodon stem-loop from a mixture of different nucleic acids. Finally, there is described a pharmaceutical composition for inhibiting the interaction of a tRNA, with a tRNA synthetase or ribosomal protein along with other related aspects.

L'invention concerne un peptide sensiblement pur comprenant la séquence suivante: [ML] -X(3) -[LIVMC] - X(3)-[GMNEHK] -[MLFYI] -X(2) -[ST] - X(3)-[SAIG] -[RMIK] -X(2) -[MIVA] -X(2) -[GNRHK] -X-[IVLF] -X-[LIV] -[NDSRGAL] -X(3) -[LIVSQ] -X(2) -[PILVTAC] dans laquelle X représente un aminoacide quelconque. Fait aussi l'objet de cette invention un procédé permettant de déterminer si un acide nucléique comprend une boucle souche d'anticodon d'ARN de transfert. L'invention concerne aussi un procédé permettant d'identifier une substance se liant à un peptide, la liaison étant décelée par analyse des conjugats, d'une substance libre ou d'un peptide non complexe et un procédé permettant de déterminer si un composé de test est un agoniste ou un antagoniste d'une interaction de boucle souche d'anticodon de la synthétase d'ARN de transfert ou une interaction de boucle souche d'anticodon de protéine S4 ribosomique d'ARN de transfert. L'invention concerne en outre un procédé permettant d'obtenir un acide nucléique sensiblement pur comprenant une boucle souche d'anticodon d'ARN de transfert extraite d'un mélange de différents acides nucléiques. L'invention concerne finalement une composition pharmaceutique permettant d'inhiber l'interaction d'un ARN de transfert avec une synthétase d'ARN de transfert ou une protéine ribosomique ainsi que qu'autres aspects associés.

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