C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/12 (2006.01) A61K 31/513 (2006.01) A61P 7/02 (2006.01) C07D 239/54 (2006.01) C07D 401/14 (2006.01) C07D 403/12 (2006.01) C07D 403/14 (2006.01) C07D 413/12 (2006.01) C07D 413/14 (2006.01)
Patent
CA 2610429
There is provided a compound of formula I wherein R1 to R5, A, G, L and X have meanings given in the description, which compounds are useful as, or are useful as prodrugs of, competitive inhibitors of trypsin-like proteases, such as thrombin, and thus, in particular, in the treatment of conditions where inhibition of thrombin is beneficial (e.g. conditions, such as thrombo- embolisms, where inhibition of thrombin is required or desired, and/or conditions where anticoagulant therapy is indicated).
L'invention concerne un composé de formule (I) dans laquelle R1 à R5, A, G, L et X ont les significations données dans la description, les composés de l'invention étant utiles comme inhibiteurs compétitifs ou comme promédicaments d'inhibiteurs compétitifs de protéases de type trypsine, telles que thrombine et, de ce fait, en particulier pour le traitement d'états pour lesquels l'inhibition est avantageuse (par exemple, des états tels que thrombo-embolismes, où l'inhibition de la thrombine est nécessaire ou souhaitable, et/ou d'états où une thérapie d'anticoagulants est indiquée).
Nilsson Ingemar
Polla Magnus
Astrazeneca Ab
Fetherstonhaugh & Co.
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