C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 451/12 (2006.01) A61K 31/46 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2443655
Compounds and methods of modulating the activity of P-glycoproteins are disclosed. The method utilizes compounds derived from Erythroxylum pervillei. the compounds overcome multidrug resistance and can be used therapeutically to enhance performance of therapeutic drugs, like chemotherapeutic drug and antibiotics.
Cette invention se rapporte à des composés et à des procédés pour moduler l'activité des P-glycoprotéines. Ce procédé utilise des composés dérivés de l'Erythroxylum pervillei. Ces composés inhibent la polypharmacorésistance et ils peuvent être utilisés thérapeutiquement pour améliorer les performances de médicaments dans certaines thérapies, tels que les médicaments chimiothérapeutiques et les antibiotiques.
Kinghorn A. Douglas
Pezzuto John M.
Smart & Biggar
The Board Of Trustees Of The University Of Illinois
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