Tropane derivatives as ccr5 modulators

Details Tropane derivatives as ccr5 modulators Tropane derivatives as ccr5 modulators

C - Chemistry, Metallurgy

07

D

C07D 519/00 (2006.01) A61K 31/46 (2006.01) A61P 29/00 (2006.01) A61P 31/18 (2006.01)

Patent

CA 2481482

The present invention provides compounds of formula (I) wherein, X, Y, R1, R2 and R2 are as defined hereinabove. The compounds of the present invention are modulators, especially antagonists, of the activity of chemokine CCR5 receptors. Modulators of the CCR5 receptor may be useful in the treatment of various inflammatory diseases and conditions, and in the treatment of infection by HIV and genetically related retroviruses.

La présente invention concerne des composés de la formule (I) où X, Y, R?1¿, R?2¿ et R?2¿ ont la définition susmentionnée. Les composés de la présente invention sont des modulateurs, notamment des antagonistes, de l'activité des récepteurs CCR5 de chémokine. Les modulateurs du récepteur CCR5 peuvent être utilisés dans le traitement de diverses maladies et états inflammatoires, et dans le traitement d'infection par le VIH et de rétrovirus liés à la génétique.

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