Trophic factor having ion channel-inducing activity in...

Details Trophic factor having ion channel-inducing activity in... Trophic factor having ion channel-inducing activity in...

C - Chemistry, Metallurgy

12

N

C12N 15/18 (2006.01) A61K 38/18 (2006.01) C07K 14/465 (2006.01) C07K 14/475 (2006.01) C07K 14/48 (2006.01) C07K 16/22 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2145769

The invention pertains to isolated neurotrophic factors, designated as ARIA, which are able to induce the formation of ion channels in a surface membrane of a cell. The amino acid sequence of the neurotrophic factors include an EGF-like domain, and a second amino acid sequence encoded by at least a portion of an exon of the neurotrophic factor gene expressible in a cell of the nervous system, such as a neuronal cell. The neurotrophic factor is distinct from, and essentially unrelated to, the chicken prion- like protein previously identified.

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