Tropolone derivatives and pharmaceutical composition thereof...

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 295/116 (2006.01) A61K 31/425 (2006.01) A61K 31/435 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) A61K 31/55 (2006.01) C07D 213/74 (2006.01) C07D 239/42 (2006.01) C07D 243/08 (2006.01) C07D 277/64 (2006.01) C07D 295/096 (2006.01) C07D 295/135 (2006.01) C07D 401/02 (2006.01) C07D 401/06 (2006.01) C07D 403/02 (2006.01) C07D 413/08 (2006.01) C07D 417/02 (2006.01)

Patent

CA 2087004

The present invention provides novel tropolone derivatives of formula (I), wherein R10 is a substituted or unsubstituted piperazinyl or benzothiazolidinyl group, and pharmaceutical compositions thereof. These compounds are useful for the prevention and treatment of ischemic diseases, including cerebrovascular diseases and cardiovascular diseases.

La présente invention offre de nouveaux dérivés de formule I de la tropolone, dans lesquels R10 est un substitut (ou pas) du groupe des pipérazinyles ou des benzothiazolidinyles, et des composés pharmaceutiques de ceux-ci. Ces composés servent à prévenir ou traiter les affections ischémiques comme les maladies cérébrovasculaires et cardiovasculaires.

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