Tropone-substituted phenyloxazolidinone antibacterial agents

Details Tropone-substituted phenyloxazolidinone antibacterial agents Tropone-substituted phenyloxazolidinone antibacterial agents

C - Chemistry, Metallurgy

07

D

C07D 263/20 (2006.01) C07D 413/10 (2006.01) C07D 417/10 (2006.01) C07D 487/04 (2006.01)

Patent

CA 2147753

A novel class of phenyloxazolidinone antibacterial agents which have, as their salient structural feature, an appended substituted tropone moiety, are described. Intermediates and processes for the preparation of these antibiotics are also disclosed. These compounds are useful antibacterial agents to eradicate or control suceptible organisms. In formula (I), R1, R2 and R3 are the same as in claim 1 and R4 is selected from the group consisting of (a), (b), (c) and (d), wherein R and R a are the same or different and are selected from the group consisting of (C1-C8) alkyl optionally substituted with chloro, fluoro, hydroxy, (C1-C8) alkoxy, amino, (C1-C8) alkylamino, (C1-C8) dialkylamino. (see formula I)

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