C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/47 (2006.01) C12N 15/12 (2006.01) C12P 21/02 (2006.01) G01N 33/15 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2312733
A stereostructure of complexes composing troponin C and an N-terminal fraction of troponin I TnI1-47 constituting troponin complexes which is clarified by the X-ray diffractometry; a troponin calcium switching mechanism which is obtained based on the above stereostructure; and a system for screening agonists affecting the troponin calcium switching. These agonists might be candidates for drugs for myocardial infarct with a novel function mechanism.
L'invention concerne une stéréostructure de complexes constitués de troponine C et d'une fraction N-terminale de troponine I TnI¿1-47?, mise en évidence selon une méthode de mesure par diffraction des rayons X. L'invention concerne également un mécanisme de commutation troponine-calcium obtenu sur la base de ladite stéréostructure. Elle concerne enfin un système de criblage d'agonistes affectant la commutation troponine-calcium. Ces agonistes peuvent s'utiliser comme médicaments présentant un nouveau mécanisme fonctionnel pour lutter contre l'infarctus du myocarde.
Maeda Kayo
Maeda Yuichiro
Takeda Soichi
Vassylyev Dmitry
Deeth Williams Wall Llp
Matsushita Electric Industrial Co. Ltd.
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